Фосфатидилинозитол

Фосфатидилинозитол

                                                                                                                                  Гормон

 Наружная мембрана                                  рецептор

                                                                                                                                                              G-белок

Фосфатидил          Фосфатидил         Фосфатидил

Инозитол                инозитол-4-ф       инозитол-4,5-Ф2

   НЖК    АТФ         НЖК     АТФ        НЖК                                            Фосфолипаза С

    АК                         АК                        АК

    ФИ                         ФИФ                     ФИФ2                                      

                                                                                                                                           Цитоплазма

                                                             Диацилглицерол                          

            НЖК     ЦТФ      НЖК    АТФ       НЖК                                   ИФ3

            АК                       АК                      АК      

            Ф+ЦМФ             Ф                                                                                        Мобилизация Ca2+

                                                                                                                                 Ca2+    Кальмодулин

                                                                                                  Са2+                     Са2+ + кальмодулин

  И                  Фосфолипаза А2                                                                      

                                                   Протеинкиназа С                                               Са2+ + кальмодулин

 Арахидоновая к-та                                                                                              + протеинкиназа

                                                  Фосфорилирование белка    Активация         Фосфорилирование Метаболиты                                                                                 белка                            белка

                                                         Биологический эффект                                 Рис.2